ATP Hydrolysis at One Site Drives the Dissociation of ATP-Binding Cassette Nucleotide-Binding Domains
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چکیده
منابع مشابه
Dissociation of ATP-binding cassette nucleotide-binding domain dimers into monomers during the hydrolysis cycle.
ATP-binding cassette (ABC) proteins have two nucleotide-binding domains (NBDs) that work as dimers to bind and hydrolyze ATP, but the molecular mechanism of nucleotide hydrolysis is controversial. In particular, it is still unresolved whether hydrolysis leads to dissociation of the ATP-induced dimers or opening of the dimers, with the NBDs remaining in contact during the hydrolysis cycle. We st...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2013
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2012.11.1255